Notification of Transactions of Directors/PDMRs

The Company has been notified of the following acquisitions of Ordinary Shares of 0.25p each in the Company, by Dr Nick Cooper, Chief Executive Officer and Dr Bill Higgs, Chief Operating Officer. The acquisitions took place in London.

Notification of Transactions of Directors/PDMRs

The Company has been notified of the following acquisitions of Ordinary Shares of 0.25p each in the Company, by Nicholas Smith, Non-Executive Chairman and Vivien Gibney and William (Bill) Schrader, both Non-Executive Directors of the Company. The acquisitions all took place in London.